TB-500 Fragment (17-23) 10mg

Introduction to TB-500 Fragment (17-23)

The TB-500 Fragment (17-23) 10mg is a specialized research peptide derived from the larger Thymosin Beta-4 (Tβ4) protein. While the full-length Tβ4 molecule consists of 43 amino acids, the (17-23) fragment—specifically the Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln sequence—is identified as the primary site responsible for actin-binding and cellular motility. At USA PEPTIDE SCIENCES, we provide this fragment in a highly purified, lyophilized form to ensure researchers can isolate and observe the specific bioactivity of this essential molecular domain without the interference of the full-length protein’s other functions.

Research Overview: Cellular Migration and Actin Dynamics

The TB-500 Fragment (17-23) is a central focus in regenerative biology and molecular mechanics research. Because this specific sequence is the minimal functional unit required to promote the migration of various cell types, it serves as a critical tool for studying the fundamental processes of tissue repair and angiogenesis.

Current laboratory investigations using the (17-23) fragment include:

• Actin Polymerization: Studying how the fragment interacts with G-actin to regulate cellular structure and movement.

• Angiogenic Modeling: Observing the migration of endothelial cells and the formation of new vascular structures in vitro.

• Dermal and Corneal Repair: Researching the speed and efficiency of epithelial cell migration in response to the fragment.

• Anti-inflammatory Signaling: Evaluating the fragment’s role in modulating the localized inflammatory response during the initial phases of tissue modeling.

Quality Standards & Analytical Testing

Precision is non-negotiable in peptide synthesis. At USA PEPTIDE SCIENCES, each batch of TB-500 Fragment (17-23) 10mg undergoes rigorous multi-step validation. We utilize High-Performance Liquid Chromatography (HPLC) to confirm a purity profile of ≥99% and Mass Spectrometry (MS) to ensure the exact amino acid sequence of the 17-23 domain. This stringent testing ensures that your research results are reproducible and free from the contaminants or truncated sequences that often plague lower-quality compounds.

Storage and Handling Requirements

To preserve the molecular stability of the TB-500 Fragment (17-23) 10mg, the lyophilized vial should be stored in a freezer at -20°C upon arrival. For active laboratory use, the peptide should be reconstituted with an appropriate sterile or bacteriostatic diluent. Once in a liquid state, the compound is more susceptible to degradation and must be stored at 2°C to 8°C. Researchers should avoid excessive physical agitation or exposure to direct light to maintain the structural integrity of the peptide sequence.

Research Use Disclaimer

The compounds provided by USA PEPTIDE SCIENCES, including TB-500 Fragment (17-23) 10mg, are strictly for laboratory research purposes only. These products are not intended for human or veterinary use, nor are they designed for diagnostic or therapeutic applications. All experiments must be conducted by qualified professionals within a controlled laboratory setting.